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类器官技术是近年来迅速发展的三维细胞培养平台，能够高度模拟人体消化器官的微结构和功能，弥补传统二维细胞模型和动物模型的局限性。通过系统梳理类器官技术在模拟消化系统生理病理状态、构建消化系统疾病模型、实现高通量药物筛选以及推动个体化治疗等方面的独特优势，进一步探讨其在中药复方关键成分筛选、药代动力学和毒理学指标的体外评价以及多靶点协同机制研究中的应用潜力。结合前沿工程技术，认为类器官有望为中医药防治消化系统疾病提供更加科学的研究平台，加速其机制研究的现代化进程，提升中医药研究的国际影响力。
Abstract：Organoid technology, a rapidly advancing three-dimensional(3D) cell culture platform, can closely mimic the microarchitecture and functions of human digestive organs, effectively overcoming the limitations of conventional two-dimensional cell models and animal experiments. By systematically summarizing the distinctive strengths of organoid technology in simulating digestive physiological and pathological states, constructing digestive system disease models, enabling high-throughput drug screening, and facilitating personalized treatment, this review explored the potential applications of organoids in identifying active components of traditional Chinese medicine(TCM) formulas, evaluating in vitro pharmacokinetics and toxicological parameters, and investigating multi-target synergistic mechanisms. By integrating cutting-edge engineering technologies, organoids are expected to provide a more scientific research platform for TCM, accelerate the modernization of its mechanistic studies, and enhance its scientific value and global impact.
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基本信息:
DOI：10.13288/j.11-2166/r.2025.14.005
中图分类号:R259
引用信息:
[1]温永天,马祥雪,张北华等.类器官技术在中医药防治消化系统疾病研究中的应用价值[J].中医杂志,2025,66(14):1433-1438.DOI:10.13288/j.11-2166/r.2025.14.005.
基金信息:
国家自然科学基金（82474496）; 中国科学技术协会第七届青年人才托举工程（2021-QNRC1-01）; 中国中医科学院科技创新工程创新团队项目（CI2021B005）