中医杂志

总结房定亚基于络病理论分期论治结缔组织病伴免疫性血小板减少症的经验。认为络脉受损是本病的基本病机，急性期以热毒伤络、血溢脉外为病机关键，治以清络解毒，凉血散血，方选犀角地黄汤加减；慢性期气血不充、络虚失荣，治宜益气养血，护脉通络，方用归脾汤化裁。久病入络，瘀结最深，非通不达，故化瘀通络法贯穿治疗全程。

This paper is to summarize professor FANG Dingya's clinical experience in staged differentiation and treatment of connective tissue disease with immune thrombocytopenia(CTD-ITP) based on collateral disease theory. It is believed that the fundamental pathological feature is collateral vessel impairment. During the acute stage, the key pathogenesis lies in heat-toxin damaging collaterals, then blood extravasation outside the vessels, for which the treat-ment focuses on clearing collaterals and resolving toxins, cooling the blood and dissipating blood stasis, prescribing with modified Xijiao Dihuang Decoction （犀角地黄汤）. During the chronic stage, characterized by deficiency of qi and blood, colla-terals failing to receive nourishment, the therapeutic principle shifts to tonifying qi and nourishing blood, protecting vessels and dredging collaterals, prescribing with modified Guipi Decoction （归脾汤）. Considering that persis-tent illness penetrates deeply into collaterals leading to blood stasis accumulates, which cannot be resolved without dredging therapy, the stasis-dissolving and collateral-dredging method should be consistently applied throughout the entire treatment course.