中医杂志

总结皮持衡教授运用温阳育阴活血法分期论治糖尿病肾病（DN）的经验。认为阳虚阴损是DN发病的关键病机，血瘀贯穿其发病始终，治疗上以温阳育阴活血为总则，临证根据分期治疗各有侧重。早期脾气亏虚、气阴不足，常投参芪地黄汤加减以益气滋阴、温阳活血；中期脾肾阳虚、湿浊内蕴，方用真武汤合三仁汤化裁以温阳利水，化湿通络；晚期瘀毒互结、阴阳两亏，施以济生肾气丸化裁以温阳育阴，消癥解毒。同时运用中药膏摩辅助治疗，标本兼顾，内外同治。

This paper summarized Professor PI Chiheng's experience in treating diabetic nephropathy(DN) using the method of warming yang, nourishing yin, and invigorating blood by stages. It is believed that yang deficiency and yin depletion are the key pathological mechanisms of DN, with blood stasis running throughout the disease's progression. The general treatment principle is to warm yang, nourish yin, and invigorate blood, with different emphases at each stage. For early stage, the disease is characterized by spleen qi deficiency and insufficiency of qi and yin, which could be treated by modified Shenqi Dihuang Decoction （参芪地黄汤） to tonify qi and invigorate blood, strengthen yang and consolidate yin; for middle stage, the disease is marked by spleen and kidney yang deficiency with internal dampness accumulation, which could be treated by modified Zhenwu Decoction （真武汤） and Sanren Decoction （三仁汤） warming yang and to resolve dampness and unblock meridians; for the late stage, the disease is characterized by blood stasis and toxin accumulation with deficiency of both yin and yang, which could be treated by modified Jisheng Shenqi Pill （济生肾气丸） to eliminate pathological masses and remove toxins, warm yang and nourish yin. Additionally, traditional Chinese medicine therapies such as rubbing with ointment(Gao Mo therapy) are utilized as adjunct treatments, treating the root and branch simultaneously and combining internal and external approaches.