中医杂志

“两个重构”理论框架通过重构中西医结合诊疗体系，建立“分类-分期-分证”标准路径，提高了疾病识别精度和全程干预能力；通过重构现代本草体系，创新性融合中药传统功效与现代药理作用，形成“态靶同调”精准用药模式，并构建方药量效理论体系，增强了干预的靶向性和剂量精确性。“两个重构”理论框架是提高临床疗效的关键，其能够实现态、靶精准锁定与定向干预；可前移防治关口，贯通疾病全周期管理；助力构建标准化诊疗范式，确保疗效稳定、可重复、可评估；突破辨证局限，推动中医药诊疗领域的拓展。“两个重构”理论框架是推动中医药创新的系统路径，可为推动中西医结合高质量发展提供参考。

By reconstructing the integrated Chinese and western medicine diagnostic and treatment system, the "Two Reconstructions" theoretical framework establishes a standardized pathway of "classification-staging-syndrome differentiation", which improves the accuracy of disease identification and strengthens the capacity for full-course intervention; in addition, by reconstructing the modern materia medica system, it innovatively integrates the traditional properties and efficacy of Chinese herbal medicinals with modern pharmacological mechanisms, forming a "state-target co-regulation" precise medication model, and builds a dose-effect theoretical system for prescriptions and medicinals, thereby enhancing both the targeting accuracy and dosage precision of therapeutic interventions. The "Two Reconstructions" theorecitcal framework is a key strategy for enhancing clinical efficacy. It can precisely identify "states" and "targets" for directed intervention, shift the focus of prevention and treatment earlier to enable full-cycle management, establish standardized paradigms for reproducible and evaluable efficacy, and expand the scope of clinical practice to address conditions without typical syndromes and critical illnesses. As a systematic pathway for innovation in TCM, this theoretical framework provides valuable insights and references for promoting the high-quality development of integrative Chinese and western medicine.