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从中医时间医学视角出发，系统探讨阴阳消长、子午流注及营卫循行等节律理论与肠易激综合征（IBS）发生发展的内在联系。认为IBS的核心病机为肝失疏泄、脾胃升降失常，而昼夜节律紊乱可通过破坏阴阳、营卫平衡，加重脏腑功能失调。生物钟基因调控的免疫节律、菌群节律、神经内分泌节律与中医学“天人相应”理论具有一致性，故提出通过顺应自然节律调整IBS治疗方案，包括时序养生调摄、时序外治疗法及时序药疗等，为IBS的临床诊疗提供思路。
Abstract：From the perspective of traditional Chinese medicine(TCM) chronomedicine, this article systematically explored the inherent connection of rhythmic theories such as the waxing and waning of yin and yang, the ebb and flow of midnight and midday, and the movement of ying and wei levels, with the occurrence and development of irritable bowel syndrome(IBS). The core pathogenesis of IBS involves the liver failing to govern the free flow of qi, and the dysfunction of the spleen and stomach in ascending and descending. Circadian rhythm disruption can further exacerbate dysfunction of zang-fu （脏 腑） organs by damaging the balance of yin-yang and ying-wei. The immune rhythm, microbiome rhythm, and neuroendocrine rhythm regulated by biological clock genes are highly consistent with the TCM theory of "correspondence between heaven and humankind". Therefore, it is proposed to adjust IBS treatment plans in accordance with natural rhythms, including temporal health preservation and management, temporal external therapies and temporal medication, in order to provide a new approach for the clinical diagnosis and treatment of IBS.
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基本信息:
DOI：10.13288/j.11-2166/r.2026.08.007
中图分类号:R259
引用信息:
[1]沈梦文,郭昕悦,王玮佳,等.肠易激综合征的中医时间医学时序治疗策略[J].中医杂志,2026,67(08):845-849.DOI:10.13288/j.11-2166/r.2026.08.007.
基金信息:
国家自然科学基金（82274399,82574902）; 江苏省中医药科技发展委托专项（2022WTZX01）
2026-04-16
2026-04-16