中医杂志

总结卢芳教授从热毒瘀络辨治系统性红斑狼疮的临床经验。认为系统性红斑狼疮总属本虚标实，核心病机为热毒瘀络，其中急性活动期以热毒燔炽、迫血成瘀为主，慢性迁延期以瘀毒阻络、气阴两虚为主。临证治疗主张“热淫于内，治以咸寒；瘀阻于络，佐以辛通”的基本治则，自拟抑免汤为基础方分期施治，急性活动期常配伍清热解毒、凉血消瘀、通络之品，慢性迁延期常配伍化瘀通络、益气养阴之品。

This paper summarizes Professor LU Fang's clinical experience in treating systemic lupus erythematosus(SLE) based on the differentiation and treatment of heat-toxin and blood-stasis in the collaterals. SLE is generally characterized by deficiency in origin with excess in manifestation. The core pathogenesis is heat-toxin obstructing the collaterals. During the acute active stage, the predominant pattern is blazing heat-toxin causing blood stasis, while in the chronic remitting stage, the main pattern is toxic stasis blocking the collaterals with qi and yin deficiency. Clinical treatment follows the basic principle that treat with salty-cold herbs, when heat invades internally and that assist with acrid-dispersing herbs when stasis obstructs the collaterals. The self-formulated Yimian Decoction （抑免汤） serves as the base formula and is applied in stages. During the acute active stage, it is often combined with herbs for clearing heat and detoxifying, cooling blood and resolving stasis, and unblocking the collaterals. In the chronic remitting stage, it is often combined with herbs for activating blood circulation and unblocking the collaterals, as well as tonifying qi and nourishing yin.