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脾主运化,包涵小肠泌别清浊及大肠传导功能,维持肠道微生物稳态;脾为精微运化之枢纽,血脂亦由脾运化水谷而生成,并依赖脾的转输功能布散周身。因此,在"脾主运化"理论的指导下,探讨肠道微生物稳态与膏脂转输的关系,将有助于从肠道微生态角度为中医学"从脾论治"心脑血管疾病提供科学依据,丰富"脾主运化"理论科学内涵。
Abstract：Spleen governing transportation and transformation includes small intestine separating the useful from the waste and large intestine conveyance to maintain intestinal microbial homeostasis. Spleen is the hub of essence transportation and transformation. Blood lipid is also formed by spleen transforming food and spreads all around the body by spleen's function of transportation. Therefore,under the guidance of the theory of "spleen governing transportation and transformation"to explore the relationship between intestinal microbial homeostasis and grease transfer may help to provide scientific basis for Chinese medicine in treating cardiovascular and cerebrovascular diseases "from spleen"from the aspect of intestinal microecology and to enrich the scientific connotation of theory of "spleen governing transportation and transformation".
[1]贾连群,杨关林,张哲,等.从“脾主运化”理论探讨膏脂转输与胆固醇逆向转运[J].中医杂志,2013,54(20):1793-1795.
[2]刘名波.香砂六君子汤对脾虚泄泻免疫功能和肠道微生态的影响[D].苏州:苏州大学,2015.
[3]吴秀.四君子汤总多糖通过肠道菌群改善脾虚小鼠免疫功能的研究[D].广州:广州中医药大学,2014.
[4]胡漫林.参苓白术散干预危重病患者肠道菌群失调的初步观察[D].广州:广州中医药大学,2013.
[5]郑贵力,王煦.王绵之教授治疗高脂血症的学术思想及经验[J].北京中医药大学学报,2000,23(2):48-50.
[6]周学文,陈民,李曦明,等.血脂异常中医病因病机探讨[J].中华中医药学刊,2007,25(2):197-198.
[7]吕玲玲.从脾论治血脂失调症研究进展[J].辽宁中医杂志,2009,36(12):2200-2202.
[8]熊文生.从脾论治高脂血症的概况与展望[J].新中医,1996,29(5):58-59.
[9]宋剑南,刘军莲,房祥忠,等.高脂血症和动脉粥样硬化不同痰瘀证候患者血浆蛋白质差异表达谱与脏腑功能的关系[J].中西医结合学报,2008,12(6):1233-1237.
[10]贾连群,杨关林,赵钢,等.化瘀祛痰方药对巨噬细胞源性泡沫细胞ABCA1、CD36表达的影响[J].辽宁中医杂志,2013,40(2):234-237.
[11]甄毕贤,贾连群,杨关林,等.高脂脾虚人群血浆HDL亚类分布特征及与血脂水平的关系[J].辽宁中医杂志,2014,41(7):1440-1443.
[12]朱美林,贾连群,陈阳,等.脾虚状态对高脂血症大鼠血清低密度脂蛋白亚类分布的影响[J].中医药导报,2015,21(14):10-13,18.
[13]VAN DENELSEN LW,POYNTZ HC,WEYRICH LS,et al.Embracing the gut microbiota:the new frontier for inflammatory and infectious diseases[J].Clin Transl Immunology,2017,6(1):e125.
[14]AMES NJ,RANUCCI A,MORIYAMA B,et al.The human microbiome and understanding the 16S rRNA gene in translational nursing science[J].Nurs Res,2017,66(2):184-197.
[15]THOMAS C,GIOIELLO A,NORIEGA L,et al.TGR5-mediated bile acid sensing controls glucose homeostasis[J].Cell Metab,2009,10(3):167-177.
[16]RYAN KK,TREMAROLI V,CLEMMENSEN C,et al.FXR is a molecular target for the effects of vertical sleeve gastrectomy[J].Nature,2014,509(7499):183-188.
[17]CHANG CJ,LIN CS,LU CC,et al.Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J].Nat Conmun,2015,6:7489.doi:10.1038/ncomms8489.
[18]GHAZALPOUR A,CESPEDES I,BENNETT BJ,et al.Expanding role of gut microbiota in lipid metabolism[J].Curr Opin Lipidol,2016,27(2):141-147.
[19]FU J,BONDER MJ,CENIT MC,et al.The gut microbiome contributes to a substantial proportion of the variation in blood lipids[J].Circ Res,2015,117(9):817-824.
[20]FENNEMA D,PHILLIPS IR,SHEPHARD EA.Trimethylamine and trimethylamine N-Oxide,a flavincontaining monooxygenase 3(FMO3)-mediated hostmicrobiome metabolic axis implicated in health and disease[J].Drug Metab Dispos,2016,44(11):1839-1850.
[21]CHEN ML,YI L,ZHANG Y,et al.Resveratrol attenuates trimethylamine-N-oxide(TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota[J].MBio2016,7(2):2210-2215.
[22]IERARDI E,SORRENTINO C,PRINCIPI M,et al.Intestinal microbial metabolism of phosphatidylcholine:a novel insight in the cardiovascular risk scenario[J].Hepatobiliary Surg Nutr,2015,4(4):289-292.
[23]TIAN L,JIA L,Mingde F,et al.Alterations of high density lipoprotein subclasses in obese subjects[J].Lipids,2006,41(8):789-796.
[24]RABOT S,MEMBREZ M,BRUNEAU A,et al.Germfree C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.[J].FASEB,2010,24(12):4948-4959.
基本信息:
DOI：10.13288/j.11-2166/r.2017.18.007
中图分类号:R259
引用信息:
[1]贾连群,宋囡,张妮,等.基于“脾主运化”理论探讨肠道微生物稳态与膏脂转输的关系[J].中医杂志,2017,58(18):1554-1557.DOI:10.13288/j.11-2166/r.2017.18.007.
基金信息:
国家自然科学基金(81774022);; 国家重点基础研究发展计划(“973”计划)(2013CB531700);; 2016年辽宁省“百千万人才工程”资助项目;; 辽宁省自然科学基金(2015020394)
2017-09-17
2017-09-17