中医杂志

认为“浊害清和”理论契合现代医学中肿瘤微环境失稳的病机特征，形成浊邪化膏、结瘀、热变、郁闭（即富脂微环境、高凝、炎性微环境及缺氧微环境）的核心病机演变过程。“黜浊”之法成为截断肿瘤转向恶性预后的核心要义，提出中气失序、浊邪化膏始酿痰浊，多以运中健脾之法利痰浊，改善肿瘤治疗耐药；血脉凝滞、浊邪结瘀促生瘀浊，故以活血调营之法散瘀浊，抑制新生血管生成和血行转移；虚火上浮、热燔浊邪终致毒浊，治以养阴解毒之法清毒浊，降低炎症反应并增强机体免疫功能；木失条达、浊邪滞缓化为郁浊，应以舒达肝木之法泄郁浊，抑制肿瘤生长发展。结合不同病势进行加减配伍，旨在靶向调控肿瘤微环境，延缓肿瘤恶性演进，冀以为肿瘤病证的精准辨治提供指导。

The theory of "turbidity impairing clarity and harmony" aligns with the pathological features of tumor microenvironment destabilization in modern medicine. It describes a core pathogenic evolution in which turbid pathogens transform into phlegm-turbidity, blood stasis, heat toxicity, and stagnation, which correspond to lipid-rich microenvironment, hypercoagulable and inflammatory microenvironment, and hypoxic microenvironment. The principle of "eliminating turbidity" becomes central to intercepting malignant prognosis of tumors. It is proposed that when center qi loses regulation, turbid pathogens transform into phlegm-turbidity, which should be treated by strengthening the spleen and regulating the middle to resolve phlegm-turbidity, thereby improving resistance to tumor therapies. When blood circulation is obstructed and turbid pathogens form stasis, promoting blood circulation and regulating the nutrient qi can disperse stasis-turbidity, inhibit angiogenesis, and prevent hematogenous metastasis. When deficient fire flares upward and heat scorches turbid pathogens into toxic turbidity, nourishing yin and detoxifying can clear toxic turbidity, reduce inflammatory responses, and enhance immune function. When the liver loses its coursing function and turbid pathogens stagnate into depressive turbidity, soothing the liver and relieving constraint can eliminate depressive turbidity, thereby suppressing tumor growth. Modifications are applied according to different stages of disease, aiming to target the regulation of the tumor microenvironment, slow malignant progression, and provide guidance for precise syndrome differentiation and treatment of tumor-related conditions.