中医杂志

认为抗肿瘤药物属攻毒之品，其峻烈偏性作用于机体后产生继发性病理因素及其病机演变，即药毒。药毒以峻猛伤正、随体从化为基本特点，脏腑受累表现为中焦先应、久及肾髓、旁及五脏，时间维度上呈急性损伤、蓄积损伤与迁延迟发的特点。癌毒、药毒与正虚相互影响，构成动态演变的复合病机格局。临证当以分期为纲、辨毒为目、扶正贯终为总纲，统筹减毒损、祛癌毒与扶正气。同时，须将药毒干预前移，贯穿抗肿瘤治疗全程，为中医药全程参与肿瘤综合治疗提供理论依据。

Antitumor drugs are considered pathogenic toxin-attacking agents,whose intense and biased pharmacological effects on the body may induce secondary pathological factors and subsequent pathological changes,that is,drug toxin.Its pathogenic features include rapid and marked impairment of healthy qi and constitution-dependent transformation.Zang-fu（脏腑） organs involvement is characterized by an early response of the middle jiao（焦）,later involvement of the kidney and marrow,and extension to the five zang organs,while its temporal evolution may manifest as acute injury,cumulative injury,and persistent or delayed injury.Cancer toxin,drug toxin,and deficiency of healthy qi interact to form a dynamically evolving complex pathogenic pattern.Clinically,treatment should take disease stage as the framework,toxin differentiation as the focus,and reinforcement of healthy qi as a principle throughout the course,while coordinating toxin reduction and elimination of cancer toxin with reinforcement of healthy qi.Furthermore,intervention against drug toxin should be initiated early and throughout the entire course of antitumor therapy.This framework may provide a theoretical basis for integrating traditional Chinese medicine throughout comprehensive cancer treatment.