李少源;荣培晶;张悦;刘兵;王磊;侯理伟;张紫璇;刘立安;何家恺;王瑜;赵斌;王艺霏;赵亚楠;陈瑜;

• 1:中国中医科学院针灸研究所
• 2:北京中医药大学

摘要(Abstract)：

中医脑病是神经系统、精神及身心系统多种疾病的统称。通过系统梳理中医古籍关于脑病治疗的相关记载,结合现代神经解剖学理论,提出基于耳穴迷走神经电刺激治疗脑病的方法;从中医"脑病耳治"理论构建出发,介绍耳穴迷走神经电刺激在抑郁症、癫痫、意识障碍、失眠障碍等脑病中的应用,为临床治疗脑病提供新思路和新方法。

关键词(KeyWords)： 脑病;耳穴;迷走神经电刺激;抑郁症;癫痫;意识障碍;失眠障碍

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划(2018YFC1705800);; 国家自然科学基金(81674072,GZ1236,82004181);; 中央级公益性科研院所基本科研业务费专项资金(ZZ201711018)

作者(Author): 李少源;荣培晶;张悦;刘兵;王磊;侯理伟;张紫璇;刘立安;何家恺;王瑜;赵斌;王艺霏;赵亚楠;陈瑜;

Email:

DOI: 10.13288/j.11-2166/r.2020.24.009

参考文献(References)：

• [1]OWEN L,CORFE B.The role of diet and nutrition on mental health and wellbeing [J].Proc Nutr Soc,2017,76(4):425-426.
• [2]NI J,HAN F,YUAN J,et al.The discrepancy of neurological diseases between china and western countries in recent two decades [J].Chin Med J,2018,131:886-891.doi:10.4103/0366-6999.229905.
• [3]WANG WZ,JIANG B,SUN HX,et al.Prevalence,incidence,and mortality of stroke in China:results from a nationwide population-based survey of 480687 adults [J].Circulation,2017,135:759-771.doi:10.1161/CIRCULATIONAHA.116.025250.
• [4]向仕平,朱成全.中西医结合脑病诊疗学[M].广州:华南理工大学出版社,2007:1.
• [5]王永炎,张伯礼.中医脑病学[M].北京:人民卫生出版社,2007.
• [6]鲍远程.中医脑病的历史源流与传承发展[J].中医药临床杂志,2013,25(3):189-192.
• [7]CARRENO FR,FRAZER A.The allure of transcutaneous vagus nerve stimulation as a novel therapeutic modality [J].Biol Psychiatry,2016,79(4):260-261.
• [8]BRANDT C,VOLK HA,LOSCHER W.Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus [J].Epilepsia,2004,45(12):1488-1497.
• [9]CASTLE M,COMOLI E,LOEWV AD.Autonomic brainstem nuclei are linked to the hippocampus [J].Neuroscience,2005,134(2):657-669.
• [10]潘大为.论王清任的神明观[J].中华中医药杂志,2009,24(2):124-127.
• [11]许富华.针刺调神理论及其临床应用研究[D].广州:广州中医药大学,2018.
• [12]王晓宇,于清泉,何伟,等.从“分子药”到“电子药”:SPARC计划和针刺研究[J].针刺研究,2019,44(3):157-160,175.
• [13]汪业汉,凌至培.神经调控技术在中国神经外科中的应用[J].军医进修学院学报,2012,33(8):806- 808.
• [14]袁媛,姜长青,陈玥,等.神经调控技术的发展与展望[J].生命科学仪器,2018,16(Z1):20-28,70.
• [15]DUGAN P,DEVINSKY O.Epilepsy:guidelines on vagus nerve stimulation for epilepsy [J].Nat Rev Neurol,2013,9:611-612.doi:10.1038/nrneurol.2013.211.
• [16]YUAN H,SILBERSTEIN SD.Vagus nerve and vagus nerve stimulation,a comprehensive review:Part I [J].Headache,2016,56(1):71-78.
• [17]FITZGERALD PB.Non-pharmacological biological treatment approaches to difficult-to-treat depression [J].Med J Aust,2013,199(S6):S48-S51.
• [18]HEIN E,NOWAK M,KIESS O,et al.Auricular transcutaneous electrical nerve stimulation in depressed patients:a randomized controlled pilot study [J].J Neural Transm (Vienna),2013,120(5):821-827.
• [19]RONG P,LIU J,WANG L,et al.Effect of transcuta-neous auricular vagus nerve stimulation on major depressive disorder:A nonrandomized controlled pilot study [J].J Affect Disord,2016,195:172-179.doi:10.1016/j.jad.2016.02.031.
• [20]DENNIS CL,DOWNSWELLl T.Interventions (other than pharmacological,psychosocial or psychological) for treating antenatal depression [J].Cochrane Database Syst Rev,2013(7):CD006795.doi:10.1002/14651858.CD006795.
• [21]WU C,LIU P,FU H,et al.Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder:a systematic review and meta-analysis [J].Medicine (Baltimore),2018,97(52):e13845.doi:10.1097/MD.0000000000013845.
• [22]KONG J,FANG J,PARK J,et al.Treating depression with transcutaneous auricular vagus nerve stimulation:state of the art and future perspectives [J].Front Psychiatry,2018,920.doi:10.3389/fpsyt.2018.00020.
• [23]FANG J,RONG P,HONG Y,et al.Transcutaneous vagus nerve stimulation modulates default mode network in major depressive disorder [J].Biol Psychiatry,2016,79(4):266-273.
• [24]LI XJ,LI W,WANG HX,et al.The effect of transcutaneous auricular vagus nerve stimulation on treatment-resistant depression monitored by resting-state fMRI and MRS:The first case report [J].Brain Stimul,2019,12:377-379.doi:10.1016/j.brs.2018.11.013.
• [25]LIU CH,YANG MH,ZHANG GZ,et al.Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression [J].J Neuroinflammation,2020,17(1):54.
• [26]TU YH,FANG JL,CAO J,et al.A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder [J].Brain Stimul,2018,11(3):501-508.
• [27]SHIOZAWA P,SILVA ME,CARVALHO TC,et al.Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders:a systematic review [J].Arq Neuropsiquiatr,2014,72(7):542-547.
• [28]CHRASTINA J,NOVAK Z,ZEMMAN T,et al.Single-center long-term results of vagus nerve stimulation for epilepsy:A 10-17 year follow-up study [J].Seizure,2018,59:41-47.doi:10.1016/j.seizure.2018.04.022.
• [29]RONG PJ,LIU AH,ZHANG JJ,et al.Transcutaneous vagus nerve stimulation for refractory epilepsy:a randomized controlled trial [J].Clin Sci (Lond),2014 .doi:10.1042/CS20130518.
• [30]OKANISHI T ,FUJIMOTO A ,Nishimura M ,et al.Insufficient efficacy of vagus nerve stimulation for epileptic spasms and tonic spasms in children with refractory epilepsy [J].Epilepsy Res,2018,140:66-71.doi:10.1016/j.eplepsyres.2017.12.010.
• [31]SONG GF,WANG HY,WU CJ,et al.A retrospective study of transcutaneous vagus nerve stimulation for post-stroke epilepsy [J] .Medicine (Baltimore),2018,97:e11625.doi:10.1097/MD.0000000000011625.
• [32]ZHAO J.Disorders of consciousness in China [J].Neurosci Bull,2018,34(4):605-614.
• [33]WU M,LI F,WU Y,et al.Impaired frontoparietal connectivity in traumatic individuals with disorders of consciousness:a dynamic brain network analysis [J].Aging Disea,2020,11(2):301-314.
• [34]YU YT,YANG Y,WANG LB,et al.Transcutaneous auricular vagus nerve stimulation in disorders of consciousness monitored by fMRI:The first case report [J].Brain Stimul,2017,10(2):328-330.
• [35]FRANSSON P,MARRELEC G.The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network:Evidence from a partial correlation network ana-lysis [J].Neuroimage,2008,42(3):1178-1184.
• [36]CORAZZOL M,LIO G,LEFEVRE A,et al.Restoring consciousness with vagus nerve stimulation [J].Curr Biol,2017,27(18):R994-R996.
• [37]HAKON J,MOGHISEH M,POULSEN I,et al.A.Transcutaneous vagus nerve stimulation in patients with severe traumatic brain injury:a feasibility trial [J].Neuromodulation,2020,10.doi:10.1111/ner.13148.
• [38]PEI W,PENG R,GU Y,et al.Research trends of acupuncture therapy on insomnia in two decades (from 1999 to 2018):a bibliometric analysis [J].BMC Complement Altern Med,2019,19(1):225.
• [39]SHI L,CHEN SJ,MA MY,et al.Sleep disturbances increase the risk of dementia:a systematic review and meta-analysis [J].Sleep Med Rev,2018,40:4-16.doi:10.1016/j.smrv.2017.06.010.
• [40]罗曼,屈箫箫,李少源,等.耳穴迷走神经刺激治疗原发性失眠症及其情感障碍35例:病例系列研究[J].中国针灸,2017,37(3):269-273.
• [41]李少源,焦玥,荣培晶,等.从褪黑素与阴阳的关系探讨失眠症的治疗[J].世界科学技术-中医药现代化,2016,18(2):270-273.
• [42]王娴,刘爱华.迷走神经刺激调节睡眠的机制研究进展[J].中风与神经疾病杂志,2015,32(12):1140-1141.
• [43]ZHAO B,LI L,JIAO Y,et al.Transcutaneous auricular vagus nerve stimulation in treating post-stroke insomnia monitored by resting-state fMRI:The first case report [J].Brain Stimul,2019,12(3):824-826.
• [44]STRUBE A,ELLRICH J,EREN O,et al.Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS):a randomized,monocentric clinical trial [J].J Headache Pain,2015,16:543.doi:10.1186/s10194-015-0543-3.